UN: Afghan opium poppy cultivation up 18 percent

KABUL, Afghanistan (AP) — Afghan efforts to stamp out opium poppy cultivation are failing because of high prices for the illicit crop, pushing farmers to grow 18 percent more in 2012 than last year, the U.N. said in a report released Tuesday.

Afghanistan is the world's largest producer of opium, the raw ingredient in heroin, providing about 80 percent of the global crop. Crop sales fund insurgents and criminal gangs in Afghanistan, making it difficult for the Afghan government to establish control in areas where the economy is driven by black-market opium sales.

Farmers planted 154,000 hectares of opium poppy in 2011, up from the 131,000 in 2011.

"An increase of 18 percent is a serious alarm signal. It is a wakeup call," said Jean-Luc Lemahieu, head of the U.N. Office on Drugs and Crime in Afghanistan, which prepared the report along with the Afghan Counternarcotics Ministry. "We are again, with regard to figures, in parallel to the high peaks of 2008, 2007, 2006.

"This country, working toward its transition, can ill afford this," he said, referring to the scheduled handover of security responsibilities to the Afghan forces from the NATO alliance by the end of 2014.

Lemahieu praised the efforts by the Counternarcotics Ministry but said the rest of the Afghan government and the country's international allies are not doing enough. He said more help is needed to provide alternatives to farmers, in law enforcement support and in cooperation from other countries in the region.

"This is an international shared responsibility," Lemahieu told reporters in Kabul.

Prices farmers receive for the crop were about $196 a kilogram this year, down from $241 a kilogram in 2011, but still far above prices from 2008 and 2009. The report said the continued high prices meant farmers were likely to plant poppy crops again in the coming season.

Most cultivation was in southern and western provinces, centers of organized crime and lax security, the report said. Restive Helmand province, long the largest producer of the crop, saw a 19 percent increase in poppy planting. Though farmers along the Helmand river valley who received international assistance planted less of the crop, this was more than offset by increases elsewhere in the province.

The Afghan government destroyed more than twice as much of the opium crop than the year before, eradicating 9,600 hectares, the report said. In 2011, the government destroyed about 3,800 hectares of opium poppy fields.

Destroying fields is dangerous in Afghanistan. Insurgents launched 177 attacks against Afghan security forces as they destroyed poppy crops this year, killing 102 soldiers and police, said Counternarcotics Minister Zarar Ahmad Muqbel.

The report indicated that despite the increase, nature limited the growth. Plant diseases and bad weather cut the potential size of the crop by 36 percent to 3,700 tons.

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'Trapped' on Broadway? R. Kelly is working on it

NEW YORK (AP) — Is Broadway ready for Twan, Sylvester, Pimp Lucius and "the package"? R. Kelly thinks so — and says he's working to bring the wacky characters and plotlines in his even wackier "Trapped in the Closet" series to the Great White Way.

The superstar announced on Monday night that he's had an offer to bring the cult classic to the stage, and he may even be in some performances.

"To transform it into a Broadway version, that's what I'm working on," he told a packed house at the Sunshine Theater, where he unveiled the latest chapters in "Trapped in the Closet," which will debut on the IFC on Friday.

Kelly gave no other details about a possible Broadway adaptation of the wildly popular video opera. It got its start from a stirring series of songs Kelly debuted in 2005, which ended with a cliff-hanger. The songs captured so much attention, Kelly made an over-the-top video series about it that just got crazier and crazier as he added more chapters.

Kelly has often referred to "Trapped" as an alien, and on Monday, he said: "I'm glad to be one of the astronauts to take this thing to the unknown."

He thanked the enthusiastic crowd for accepting the series, and admitted that he always wanted to act: "Somehow, I landed 'Trapped in the Closet' from being silly."

He also joked about the ridiculous nature of the series.

"I'm just having a lot of fun. I don't have a job so I sit in the studio all day and think of stuff to do and this is just something stupid I've done that's been successful for me," he said. "I'm having a lot of fun with it."

The latest chapters introduce a few new faces, and like the others series, ends with a cliffhanger. While it's taken Kelly five years to add these latest chapters to the series, Kelly says he won't take as long to produce more.

"I want everybody to know I've got 85 chapters of 'Trapped in the Closet' waiting in the studio for y'all," he said. "The chapters that are coming — the show, we call it — is going to exceed every chapter that you have ever seen."

Kelly capped of the evening with a rendition of one of his biggest hits, "I Believe I Can Fly," for the audience.

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http://www.r-kelly.com

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Nekesa Mumbi Moody is the AP's Global Entertainment & Lifestyles Editor. Follow her at http://www.twitter.com/nekesamumbi

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New push for most in US to get at least 1 HIV test

WASHINGTON (AP) — There's a new push to make testing for the AIDS virus as common as cholesterol checks.

Americans ages 15 to 64 should get an HIV test at least once — not just people considered at high risk for the virus, an independent panel that sets screening guidelines proposed Monday.

The draft guidelines from the U.S. Preventive Services Task Force are the latest recommendations that aim to make HIV screening simply a routine part of a check-up, something a doctor can order with as little fuss as a cholesterol test or a mammogram. Since 2006, the Centers for Disease Control and Prevention also has pushed for widespread, routine HIV screening.

Yet not nearly enough people have heeded that call: Of the more than 1.1 million Americans living with HIV, nearly 1 in 5 — almost 240,000 people — don't know it. Not only is their own health at risk without treatment, they could unwittingly be spreading the virus to others.

The updated guidelines will bring this long-simmering issue before doctors and their patients again — emphasizing that public health experts agree on how important it is to test even people who don't think they're at risk, because they could be.

"It allows you to say, 'This is a recommended test that we believe everybody should have. We're not singling you out in any way,'" said task force member Dr. Douglas Owens of Stanford University and the Veterans Affairs Palo Alto Health Care System.

And if finalized, the task force guidelines could extend the number of people eligible for an HIV screening without a copay in their doctor's office, as part of free preventive care under the Obama administration's health care law. Under the task force's previous guidelines, only people at increased risk for HIV — which includes gay and bisexual men and injecting drug users — were eligible for that no-copay screening.

There are a number of ways to get tested. If you're having blood drawn for other exams, the doctor can merely add HIV to the list, no extra pokes or swabs needed. Today's rapid tests can cost less than $20 and require just rubbing a swab over the gums, with results ready in as little as 20 minutes. Last summer, the government approved a do-it-yourself at-home version that's selling for about $40.

Free testing is available through various community programs around the country, including a CDC pilot program in drugstores in 24 cities and rural sites.

Monday's proposal also recommends:

—Testing people older and younger than 15-64 if they are at increased risk of HIV infection,

—People at very high risk for HIV infection should be tested at least annually.

—It's not clear how often to retest people at somewhat increased risk, but perhaps every three to five years.

—Women should be tested during each pregnancy, something the task force has long recommended.

The draft guidelines are open for public comment through Dec. 17.

Most of the 50,000 new HIV infections in the U.S. every year are among gay and bisexual men, followed by heterosexual black women.

"We are not doing as well in America with HIV testing as we would like," Dr. Jonathan Mermin, CDC's HIV prevention chief, said Monday.

The CDC recommends at least one routine test for everyone ages 13 to 64, starting two years younger than the task force recommended. That small difference aside, CDC data suggests fewer than half of adults under 65 have been tested.

"It can sometimes be awkward to ask your doctor for an HIV test," Mermin said — the reason that making it routine during any health care encounter could help.

But even though nearly three-fourths of gay and bisexual men with undiagnosed HIV had visited some sort of health provider in the previous year, 48 percent weren't tested for HIV, a recent CDC survey found. Emergency rooms are considered a good spot to catch the undiagnosed, after their illnesses and injuries have been treated, but Mermin said only about 2 percent of ER patients known to be at increased risk were tested while there.

Mermin calls that "a tragedy. It's a missed opportunity."

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Clinton heads to Mideast amid Gaza crisis

GAZA CITY, Gaza Strip (AP) — Efforts to end a week-old convulsion of Israeli-Palestinian violence drew in the world's top diplomats on Tuesday, with President Barack Obama dispatching his secretary of state to the region on an emergency mission and the U.N. chief appealing from Cairo for an immediate cease-fire.

Israel and Gaza's militant Hamas rulers have staked out tough, hard-to-bridge positions, and the gaps keep alive the threat of an Israeli ground invasion. On Tuesday, grieving Gazans were burying militants and civilians killed in ongoing Israeli airstrikes, and barrages of rockets from Gaza sent terrified Israelis scurrying to take cover.

From Egypt, U.N. chief Ban Ki-moon said he came to the region because of the "alarming situation."

"This must stop, immediate steps are needed to avoid further escalation, including a ground operation," Ban said. "Both sides must hold fire immediately ... Further escalation of the situation could put the entire region at risk."

U.S. Secretary of State Hillary Rodham Clinton departed for the Mideast on Tuesday from Cambodia, where she had accompanied Obama on a visit. Clinton is to meet with Israeli Prime Minister Benjamin Netanyahu in Jerusalem, Palestinian President Mahmoud Abbas in the West Bank and Egyptian leaders in Cairo, according to U.S. and Palestinian officials.

The U.S. considers Hamas, which has killed hundreds of Israelis in suicide and other attacks, to be a terror group and does not meet with its officials. Washington blames Hamas rocket fire for the latest eruption of violence and says Israel has the right to defend itself. At the same time, it has cautioned that a ground invasion could send casualties spiraling.

By Tuesday, 115 Palestinians, including 54 civilians, have been killed since Israel mounted an air onslaught that has so far included nearly 1,500 strikes. Some 840 people have been wounded, including 225 children, Gaza health officials said.

Three Israeli civilians have also been killed and dozens wounded since the fighting began last week, the numbers possibly kept down by a rocket-defense system Israel developed with U.S. funding. More than 1,000 rockets have been fired at Israel this week, the military said.

Netanyahu said Tuesday that Israel wouldn't balk at a broader military operation.

"I prefer a diplomatic solution," Netanyahu said in a statement after meeting with Germany's foreign minister, Guido Westerwelle, who is also in the region trying to advance peace efforts. "But if the fire continues, we will be forced to take broader measures and will not hesitate to do so."

Successive Israeli governments have struggled to come up with an effective policy toward Hamas.

Neither Israel's economic blockade of the territory of 1.6 million people nor bruising military strikes have cowed Gaza's Islamists, weakened their grip on the coastal strip or fire rockets at the Jewish state.

An Israeli ground invasion would risk Israeli troop losses, and could send the number of Palestinian civilian casualties ballooning — a toll Israel could be reluctant to risk just four years after its last invasion drew allegations of war crimes.

Still, with Israeli elections just two months away, polls show Israeli public sentiment has lined up staunchly behind the Netanyahu government's offensive.

Turkey's foreign minister and a delegation of Arab League foreign ministers headed to Gaza on Tuesday on a separate truce mission. Before setting off, Foreign Minister Ahmet Davutoglu signaled Turkey was in contact with Israel bout a truce — an important development given the two countries' chilly ties.

"We would be involved in all kinds of efforts if it amounted to saving the life of a single brother from Gaza," Davutoglu said. "We are determined to keep all direct or indirect channels (of dialogue) open."

Turkey's once-close ties with Israel frayed badly over the high civilian toll during Israel's 2009 war in Gaza.

With tens of thousands of Israeli soldiers dispatched to the Gaza border, awaiting a possible order to invade, the truce missions were all the more urgent.

Egypt, the traditional mediator between Israel and the Arab world, has been at the center of recent diplomatic efforts.

Israel demands an end to rocket fire from Gaza and a halt to weapons smuggling into Gaza through tunnels under the border with Egypt. It also wants international guarantees that Hamas will not rearm or use Egypt's Sinai region, which abuts both Gaza and southern Israel, to attack Israelis.

Hamas wants Israel to halt all attacks on Gaza and lift tight restrictions on trade and movement to and from the territory imposed after Hamas seized Gaza by force in 2007. Israel has rejected such demands in the past.

Resurgent rocket fire set off the Israeli offensive, launched with the assassination of the Hamas military chief and followed by hundreds of airstrikes on militant rocket launchers and weapons stores.

The onslaught turned deadlier over the weekend, as airstrikes began targeting the homes of suspected Hamas activists, leading to a spike in civilian casualties. Israel sent warnings in some cases, witnesses said, but in other instances missiles hit suddenly, burying residents under the rubble of their homes.

Hamas is deeply rooted in densely populated Gaza, and the movement's activists live in the midst of ordinary Gazans. Israel says militants are using civilians as human shields, both for their own safety and to launch rocket strikes from residential neighborhoods.

In one case, a senior member of the military wing of Islamic Jihad rented a small apartment in a 15-story high-rise of offices and news outlets. The militant, Ramez Harb, was killed Monday in a rocket strike that damaged the building.

One journalist said he and others were furious that Harb had apparently used their building as a hideout, putting others at risk. He spoke on condition of anonymity because he feared repercussions from Gaza militants.

Early Tuesday, Israeli aircraft targeted another Hamas symbol of power, the headquarters of a bank senior Hamas officials set up to sidestep international sanctions on the militant group's rule. After Hamas overran Gaza, foreign lenders stopped doing business with its militant-led government, afraid of running afoul of international terror financing laws.

The inside of the bank was destroyed and a building supply business in the basement was damaged.

"I'm not involved in politics," said the business owner, Suleiman Tawil. "I'm a businessman. But the more the Israelis pressure us, the more we will support Hamas."

Israel and Gaza's militants have a long history of fighting, but the dynamics have changed radically since they last warred four years ago. Though their hardware is no match for the Israeli military, militants have upgraded their capabilities with weapons smuggled in from Iran and Libya, Israeli officials claim.

Only a few years ago, tens of thousands of Israelis were within rocket range. Today those numbers have swollen to 3.5 million, as the militants' improved weapons reached Tel Aviv and Jerusalem for the first time this past week.

Hamas, a branch of the region-wide Muslim Brotherhood, is also negotiating from a stronger position than four years ago. At that time, Hamas was internationally isolated; now, the Muslim Brotherhood is in power in Egypt and Tunisia, and Hamas is also getting political support from Qatar and Turkey.

At home, too, the military offensive has shored up Hamas at a time when it was riven by internal divisions over its direction and the new Egyptian government's refusal to lift the blockade it imposed along with Israel after Hamas seized the territory.

This newfound backing contrasts radically with the loss of stature the Western-backed Palestinian President Mahmoud Abbas has endured as Palestinians lose faith in his ability to bring them a state through negotiations with Israel.

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Teibel reported from Jerusalem. With contributions from Ibrahim Barzak in Gaza City and Suzan Fraser in Ankara, Turkey.

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China's Xi warns party of corruption scourge

BEIJING (AP) — China's new leader Xi Jinping is highlighting corruption as a scourge that could bring down the Communist Party, though he has yet to offer any specific new proposals to stop it.

In a weekend speech that was carried Monday by the official Xinhua News Agency, Xi told the new 25-member Politburo that the party must be vigilant against graft, noting that corruption in other countries in recent years has prompted major social unrest and the collapse of governments.

"The large number of facts tells us that if the problem of corruption becomes increasingly severe, it will lead to the ruin of the party and the country!" Xinhua quoted Xi as saying in a speech that can be read as an indication of the priorities of the incoming administration.

Xi's language was unusually direct for a top leader, indicating his seriousness about the problem, but his speech gave few indications of how the party could better police itself, said Jean-Pierre Cabestan, a political scientist at Hong Kong Baptist University.

"He used strong words. It was clearly a warning: 'We have to do something about this,'" Cabestan said. "Clearly, for him, the crux of the matter is corruption. The trouble is, of course, that he doesn't tell us much about what are going to be the efficient tools or weapons he will put together to fight corruption."

Several corruption investigations have targeted high-level leaders in recent years, most notably former Politburo member Bo Xilai, who was purged this year after an aide disclosed that Bo's wife murdered a British businessman. Bo is accused of obstructing the investigation into the murder as well as unspecified corruption while in office.

Foreign media, meanwhile, have reported in recent weeks that the families of Chinese leaders have accumulated enormous wealth.

Xi urged officials at all levels to obey anti-corruption regulations and to better limit their relatives or associates from abusing their influence for personal gain, but he gave no indication of any independent mechanism for investigating graft.

The party, which controls courts, police and prosecutors, has proved feeble in policing itself yet does not want to undermine its control by empowering an independent body. Some officials have been required to report income, real estate holdings and other wealth to their superiors since 2010, but the measure has done little to staunch graft.

Xi took over as China's top leader last Thursday when he assumed the posts of party leader and head of the military commission from President Hu Jintao. Hu will retain the title of president — the ceremonial head of state — until next spring, when he hands that position to Xi as well.

Xi has been gradually replacing key Hu-appointed party officials.

On Monday, former public security minister Meng Jianzhu was named head of the Political Science and Law Commission that oversees police and the courts, replacing Zhou Yongkang.

Zhao Leji, the former party boss of the northern province of Shaanxi, was named the new head of the Organization Department responsible for key government and party appointments. He takes over from Li Yuanchao, a Hu ally who last week failed to gain a seat on the all-powerful Politburo Standing Committee.

In his remarks to the Politburo, Xi dwelled on the importance of the party's theoretical foundations in Marxism, Leninism and the ideas espoused by his predecessors, but his remarks on corruption stood out for being relatively free of political jargon.

Xi also emphasized the need to narrow the gap between the party and the people in what seemed like an implicit critique of his predecessors, said Willy Lam, a political analyst at the Chinese University of Hong Kong.

Lam said Xi's frequent references to "the people" in his speech indicated that "the past two decades have resulted somehow in the people feeling alienated from the party."

"Now what he's saying is that from day one is that we shall stick to the people. We will do what the people want," Lam said.

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Online gaming firms urge EU to open up markets

LONDON (Reuters) – Online gaming companies have accused Belgium and Greece of keeping them out of their markets illegally and urged European competition authorities to take action.

A long-running dispute over licenses in Belgium made headlines last week when Belgian authorities questioned one of the co-chief executives of bwin.party, the world’s largest listed online gaming group.

The bwin.party case has underlined the problems faced by companies in the growing online gaming sector when they operate in countries where regulations are unclear or restrictive.

Bwin.party says it is losing 700,000 euros ($ 889,400) in gaming revenue each month after access to its websites was blocked in Belgium.

Executives from 12 gaming companies including bwin.party said the European Commission had failed to follow through on concerns over Belgian laws first raised in 2009.

“We hope that the Commission will now enforce compliance with the European treaty and do so swiftly,” they said in a letter to the Financial Times.

“Countries such as Belgium and Greece that are in clear breach of EU law and that are seeking to enforce those laws domestically are likely to be at the top of the list,” it added.

“The time for polite rhetoric is now over. It is time for deeds not words.”

Belgian rules state that a company must offer the same services both online and offline to obtain a license. Opponents say that favors companies based in Belgium and means pure online providers cannot operate.

In Greece, bookmakers including Britain’s William Hill launched a legal challenge to monopoly operator OPAP after being denied licenses.

(Writing by Keith Weir; Editing by Tom Pfeiffer)

Internet News Headlines – Yahoo! News

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Justin Bieber gets love at American Music Awards

Justin Bieber may be Canadian, but he was the all-American boy at Sunday night's American Music Awards.

The pop singer dominated the awards show, winning three trophies, including artist of the year. His mom joined him onstage as he collected the award, beating out Rihanna, Maroon 5, Katy Perry and Drake.

"I wanted to thank you for always believing in me," Bieber said, looking to his mom.

The 18-year-old also won the honor in 2010. He said it's "hard growing up with everyone watching me" and asked that people continue to believe in him.

But the teenager who brought his mom as a date also got in some grinding with Nicki Minaj — who shared the stage with him and took home two awards — and a kiss on the neck from presenter Jenny McCarthy.

"Wow. I feel violated right now," he said, laughing.

"I did grab his butt," McCarthy said backstage. "I couldn't help it. He was just so delicious. So little. I wanted to tear his head off and eat it."

Another collaboration was the night's most colorful performance: Korean rapper PSY and MC Hammer. Hammer joined the buzzed-about pop star for his viral hit "Gangnam Style." PSY rocked traditional "Hammer" pants as they danced to his jam and to Hammer's "Too Legit to Quit."

Minaj, who wore three different wigs and four outfits throughout the night, repeated her AMAs wins from last year, picking up trophies for favorite rap/hip-hop artist and album for "Pink Friday: Roman Reloaded." She was in an all-white get-up, including fur coat and pink hair when she performed her new song "Freedom." The scene was ghostly and snowy, as a choir — also in white — joined her onstage. One background singer stole the performance, belting semi-high notes as Minaj looked on.

Usher kicked off the three-hour show with green laser lights beaming onstage as he performed a medley of songs, including "Numb," ''Climax" and "Can't Stop, Won't Stop," which featured a smoky floor and a number of backup dancers, as Usher jammed in all black, with the exception of his red shoes. He won favorite soul/R&B male artist.

His protege Bieber won favorite pop/rock male artist in the first award handed out and gave a shout-out to those who didn't think he would last on the music scene.

"I want to say this is for all the haters who thought I was just here for one or two years. I feel like I'm going to be here for a very long time," he said.

He also won favorite pop/rock album for his platinum-selling third album, "Believe." He gave a stripped down, acoustic performance of "As Long As You Love Me," then transitioned to the dance-heavy "Beauty and a Beat," where Minaj joined him onstage, grinding with the teen for a few seconds.

Swift won her fifth consecutive award for favorite country female artist.

"This is unreal. I want to thank the fans. You guys are the ones who voted on this," she said.

Swift gave a masquerade-themed performance of the pop song "I Knew You Were Trouble." She sang onstage in a light dress while dancers wore mostly black. But then she changed into a red corset and black skirt, matching their dark mood. She even danced and sang on the floor as lights flickered throughout the performance.

Dick Clark, who created the AMAs, was remembered by Ryan Seacrest and an upbeat performance by Stevie Wonder.

"What a producer he was," said Seacrest, as Wonder sang his hits, including "My Cherie Amour."

Carly Rae Jepsen, who performed early in the night, won favorite new artist.

"I am floored. Wow," she said, thanking Bieber and his manager, Scooter Braun.

Party girl Ke$ha was glammed up on the red carpet, rocking long, flowy blonde hair and a light pink dress. She switched to her normal attire when she performed her hit single "Die Young." It was tribal, with shirtless dancers in skin-tight pants, silver hair and skeleton-painted faces, who also played the drums. Ke$ha was pants-less, rocking knee-high boots and rolling on the floor as she finished up the song.

Minaj and Christina Aguilera were blonde bombshells, too: Minaj's hair was busy and full of volume and she sported a neon strapless gown to accept her first award. Aguilera wore a blonde bob in a purple dress that matched her eyeshadow.

Aguilera performed a medley of material from her new album and joined Pitbull onstage.

Kelly Clarkson also hit the stage, making a nod to her "American Idol" roots with a number on her dress and three judges looking on as she sang "Miss Independent." Then she went into "Since U Been Gone," ''Stronger" and "Catch My Breath."

Fellow "Idol" winner Carrie Underwood won best favorite country album and performed, hitting the right notes while singing "Two Black Cadillacs." She talked about singing competition shows backstage.

"These people that go on these shows are so talented, you know? And I would love to see if so many of the other artists that are out there today would go back and try out for these shows, because they might get their behinds kicked by some of the contestants," she said.

Luke Bryan won favorite country male artist and Lady Antebellum favorite country group.

American Music Awards nominees were selected based on sales and airplay, and fans chose the winners by voting online. At this award show, even the stars were fans: Pink said on the red carpet that she'd like to collaborate with Lauryn Hill. Cyndi Lauper said her musical playlist includes Pink and Minaj. Boy band The Wanted said they were excited to see PSY and Colbie Caillat wanted to watch No Doubt.

"What makes the American Music Awards special is the fans choose the winning artists," said Chester Bennington of Linkin Park, who won favorite alternative rock artist and performed "Burn It Down," as Brandy sang along and Gwen Stefani, Usher and Phillip Phillips bobbed their heads.

David Guetta won the show's first-ever electronic dance music award. Non-televised awards went to Katy Perry for pop/rock female artist, Beyonce for soul/R&B female artist, Adele for adult contemporary artist and Shakira for Latin artist.

Along with Rihanna, Minaj was the top nominee with four nominations.

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AP Entertainment Writer Sandy Cohen contributed to this report from Los Angeles.

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Follow Mesfin Fekadu on Twitter at http://twitter.com/MusicMesfin

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EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

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Palestinian civilian toll climbs in Gaza

GAZA CITY, Gaza Strip (AP) — Israeli aircraft struck crowded areas in the Gaza Strip on Monday, driving up the civilian death toll and in one case devastating several homes belonging to one clan — the fallout from a new tactic in Israel's six-day-old offensive meant to quell Hamas rocket fire on Israel.

Escalating its bombing campaign, Israel on Sunday began attacking homes of activists in Hamas, the Islamic militant group that rules Gaza. These attacks have led to a sharp spike in civilian casualties, killing 24 civilians in less than 24 hours, a Gaza health official said. Overall, the offensive that began Wednesday killed 91 Palestinians, including 50 civilians.

The rising civilian toll was likely to intensify pressure on Israel to end the fighting. Hundreds of civilian casualties in an Israeli offensive in Gaza four years ago led to fierce international condemnation of Israel.

Hamas fighters, meanwhile, have fired hundreds of rockets into Israel in the current round of fighting, including 12 on Monday, among them one that hit an empty school.

The new airstrikes came as Egypt was trying to broker a cease-fire, with the help of Turkey and Qatar. The Turkish foreign minister and a delegation of Arab foreign ministers were expected in Gaza on Tuesday. However, Israel and Hamas appeared far apart in their demands, and a quick end to the fighting seemed unlikely.

In Monday's violence, a missile struck a three-story home in the Gaza City's Zeitoun area, flattening the building and badly damaging several nearby homes. Shell-shocked residents searching for belongings climbed over debris of twisted metal and cement blocks in the street.

The strike killed two children and two adults, and injured 42 people, said Gaza heath official Ashraf al-Kidra.

Residents said Israel first sent a warning strike at around 2 a.m. Monday, prompting many residents in the area to flee their homes. A few minutes later, heavy bombardment followed.

Ahed Kitati, 38, had rushed out after the warning missile to try to hustle people to safety. But he was fatally struck by a falling cinderblock, leaving behind a pregnant wife, five young daughters and a son, the residents said.

Sitting in mourning with her mother and siblings just hours after her father's death, 11-year-old Aya Kitati clutched a black jacket, saying she was freezing, even though the weather was mild. "We were sleeping, and then we heard the sound of the bombs," she said, then broke down sobbing.

Ahed's brother, Jawad Kitati, said he plucked the lifeless body of a 2-year-old relative from the street and carried him to an ambulance. Blood stains smeared his jacket sleeve.

Another clan member, Haitham Abu Zour, 24, woke up to the sound of the warning strike and hid in a stairwell. He emerged to find his wife dead and his two infant children buried under the debris, but safe.

Clan elder Mohammed Azzam, 61, denied that anyone in his family had any connections to Hamas.

"The Jews are liars," he said. "No matter how much they pressure our people, we will not withdraw our support for Hamas."

Late Sunday, an Israeli missile killed a father and his eight-year-old son on the roof of their Gaza City home. The father, a Hamas policeman, was on the roof to repair a leaking water tank, his relatives said.

In another area of Gaza City, the patriarch of the Daloo family, Jamal, sat in mourning for 11 members of his family killed in a missile strike on his home Sunday. Among the dead were his wife, his son, daughter-in-law, his sister and four grandchildren. His face swollen from crying, he embraced relatives and neighbors paying their condolences.

The mourners sat in plastic chairs just meters away from bulldozers clearing the ruins of Daloo's home. His 16-year-old daughter Yara was still missing and believed under the rubble, family members said.

Daloo, who is left with two sons, tried to take comfort in the belief that the loss of his family was God's will and that the dead are now in paradise. He vehemently disputed Israel's initial claim that a senior operative of Islamic Jihad, a smaller sister group of Hamas, was hiding in his house. He said his son Mohammed, one of those killed, was a policeman in the Gaza police, but not an activist.

"The international public opinion witnessed the facts," he said of the tragedy that befell him. "This does not require my words."

Also Monday, Israel bombarded the remains of the former national security compound in Gaza City. Flying shrapnel killed one child and wounded others living nearby, al-Kidra said. Five farmers were killed in two separate strikes, al-Kidra said, including three who he said had been mistakenly identified earlier by Hamas security officials as Islamic Jihad fighters.

Other strikes killed two fighters on a motorcycle in southern Gaza and two passengers in a taxi that had put a press signs in the windshield, al-Kidra said.

In addition to 91 Palestinians killed over the past six days, some 720 were wounded, al-Kidra said.

On the Israeli side, three civilians have died from Palestinian rocket fire and dozens have been wounded. An Israeli rocket-defense system has intercepted hundreds of rockets bound for populated areas.

Israeli police spokesman Micky Rosenfeld said 12 rockets had struck Israel by late Monday morning, including one that hit a school. Schools in southern Israel have been closed since the offensive started.

Israel launched the current offensive after months of intensifying rocket fire from the Gaza Strip, which continued despite the strikes.

In the night from Sunday to Monday, aircraft targeted about 80 militant sites, including underground rocket-launching sites, smuggling tunnels and training bases, as well as Palestinian command posts and weapons storage facilities located in buildings owned by militant commanders, the Israeli military said in a release. Aircraft and gunboats joined forces to attack Hamas police headquarters, and Palestinian rocket squads were struck as they prepared to fire, the release said.

In all, 1,350 targets in the Gaza Strip have been struck since the Israeli operation began. However, military activity over the past two nights has dropped off as targets change and international efforts to wrest a cease-fire plod ahead.

Israel and Hamas have put forth widely divergent conditions for a truce. But failure to end the fighting threatens to touch off an Israeli ground invasion, for which thousands of soldiers, backed by tanks and armored vehicles, have already been mobilized and dispatched to Gaza's border.

President Barack Obama said he was in touch with players across the region in hopes of halting the fighting. While defending Israel's right to defend itself against the rocket fire, he also warned of the risks the Jewish state would take if it were to expand its air assault into a ground war.

"If we see a further escalation of the situation in Gaza, the likelihood of us getting back on any kind of peace track that leads to a two-state solution is going to be pushed off way into the future," Obama said.

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Associated Press writer Amy Teibel in Jerusalem contributed reporting.

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Obama, on Asia trip, first pays visit to Thailand

BANGKOK (AP) — President Barack Obama on Sunday launched a three-day Southeast Asia tour, hailing alliances with countries such as Thailand as cornerstones of the administration's deeper commitment to the Asia-Pacific region.

While in Asia, however, Obama will be dividing his attention by monitoring the escalating conflict between Israel and the Hamas-ruled Gaza Strip. Obama has been in regular contact with Israeli Prime Minister Benjamin Netanyahu as well as with Egyptian and Turkish leaders who might hold sway with the Hamas leadership.

Obama landed in Bangkok Sunday afternoon, greeted by 40 saluting military guards who flanked both sides of a red carpet.

His schedule is packed with sightseeing, a royal audience with King Bhumibol Adulyadej, a private meeting with Prime Minister Yingluck Shinawatra, a joint press conference and an official dinner.

On a steamy day, Obama began with a visit to the Wat Pho Royal Monastery, a cultural must-see in Bangkok. In stocking feet, the president and Secretary of State Hillary Rodham Clinton walked around a golden statue of a sitting Buddha. The complex is a sprawling display of buildings with colorful spires, gardens and waterfalls.

Obama is also visiting Myanmar and Cambodia in his first trip abroad since winning a second term.

The visit to Thailand, less than 18 hours long, is a gesture of friendship to a long-standing partner and major non-NATO ally.

Still, the two countries have faced strains, most recently after the 2006 military coup that deposed Prime Minister Thaksin Shinawatra, and Obama's visit offers an opportunity to restate and broaden the relationship.

"It was very important for us to send a signal to the region that allies are going to continue to be the foundation of our approach" to establishing a more prominent presence in Asia, deputy national security adviser Ben Rhodes told reporters traveling with the president aboard Air Force One.

Obama is also seeking to open new markets for U.S. businesses; the United States is Thailand's third biggest trading partner, behind China and Japan. Becoming a counterweight to China in the region is a keystone of Obama's so-called pivot to the Asia-Pacific region.

Obama's trip comes on the heels of meetings in Thailand between Secretary of Defense Leon Panetta and his Thai counterparts on security and military cooperation on issues ranging from fighting weapons proliferation to disaster relief to countering piracy.

Alluding to the 2006 coup, Obama's national security adviser, Tom Donilon, said in a speech ahead of the trip last week that Obama would build on Panetta's outreach to reinforce the relationship and "support the continued peaceful restoration of democratic order after a turbulent period."

After his time at the temple, Obama paid a courtesy call to the ailing, 84-year-old U.S.-born King Bhumibol Adulyadej in his hospital quarters. The king, the longest serving living monarch, was born in Cambridge, Mass., and studied in Europe.

The centerpiece of the Asia trip comes Monday when Obama travels to Myanmar, the once reclusive and autocratic state that has begun instituting democratic measures. Obama has eased sanction on the country, also known as Burma, and his visit will be the first there by a sitting U.S. president.

Obama aides see Myanmar as not only a success story but also as a signal to other countries that the U.S. will reward democratic behavior.

"If Burma can continue to succeed in a democratic transition, then that can potentially send a powerful message regionally and around the world...that if countries do take the right decisions, we have to be there with incentives," Rhodes said.

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